Description: Total Synthesis of Natural Products with Antimicrobial Activity Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Andrew Giltrap Format: Hardback Publisher: Springer Verlag, Singapore, Singapore Imprint: Springer Verlag, Singapore ISBN-13: 9789811088056, 978-9811088056 Synopsis This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
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Book Title: Total Synthesis of Natural Products with Antimicrobial Activity
Number of Pages: 268 Pages
Publication Name: Total Synthesis of Natural Products with Antimicrobial Activity
Language: English
Publisher: Springer Verlag, Singapore
Item Height: 235 mm
Subject: Medicine, Chemistry
Publication Year: 2018
Type: Textbook
Item Weight: 606 g
Author: Andrew Giltrap
Item Width: 155 mm
Series: Springer Theses
Format: Hardcover
