Description: Total Synthesis of Indole Alkaloids by Junpei Matsuoka This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds. Back Cover This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A-F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds. Author Biography Junpei Matsuoka is a research associate at the Department of Medicinal Chemistry, Doshisha Womens College of Liberal Arts. His research interests include the development of transition-metal-catalyzed reactions as well as the total synthesis of natural products. He received his bachelors degree from Meijo University in 2016 and his Ph.D. degree from Kyoto University in 2020. During his Ph.D. program, he was supported by a research fellowship for young scientists by the Japan Society for the Promotion of Science. He was awarded the Pharmaceutical Society of Japan Kansai Branch Award for Young Scientists. Table of Contents 1. Introduction.- 2. Total Synthesis of Dictyodendrin A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles.- 3. Construction of the Pyrrolo[2,3-d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide. Feature Nominated as an outstanding Ph.D. thesis by Kyoto University Provides novel strategies for the construction of pyrrolocarbazole core structures Explains the design and development of divergent synthesis of natural products Details ISBN9811586543 Author Junpei Matsuoka Short Title Total Synthesis of Indole Alkaloids Pages 82 Series Springer Theses Language English Year 2021 ISBN-10 9811586543 ISBN-13 9789811586545 Format Paperback Publisher Springer Verlag, Singapore Edition 1st Imprint Springer Verlag, Singapore Place of Publication Singapore Country of Publication Singapore Publication Date 2021-09-20 UK Release Date 2021-09-20 Illustrations 4 Illustrations, color; 73 Illustrations, black and white; XII, 82 p. 77 illus., 4 illus. in color. Subtitle Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations Edition Description 1st ed. 2020 Alternative 9789811586514 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:135430336;
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ISBN-13: 9789811586545
Book Title: Total Synthesis of Indole Alkaloids
Subject Area: Chemical Engineering
Item Height: 235 mm
Item Width: 155 mm
Author: Junpei Matsuoka
Publication Name: Total Synthesis of Indole Alkaloids: Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations
Format: Paperback
Language: English
Publisher: Springer Verlag, Singapore
Subject: Chemistry
Publication Year: 2021
Type: Textbook
Item Weight: 163 g
Number of Pages: 82 Pages
